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Review Article| Volume 50, ISSUE 4, P415-423, October 2019

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The Current Status of Cell-Based Therapies for Primary Knee Osteoarthritis

Published:August 06, 2019DOI:https://doi.org/10.1016/j.ocl.2019.06.001

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      References

        • Pitcher M.H.
        • Von Korff M.
        • Bushnell M.C.
        • et al.
        Prevalence and profile of high-impact chronic pain in the United States.
        J Pain. 2019; 20: 146-160
        • Wallace I.J.
        • Worthington S.
        • Felson D.T.
        • et al.
        Knee osteoarthritis has doubled in prevalence since the mid-20th century.
        Proc Natl Acad Sci U S A. 2017; 114: 9332-9336
        • Buckley R.H.
        Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: longterm outcomes.
        Immunol Res. 2011; 49: 25-43
        • Alcerro J.C.
        • Lavernia C.J.
        Stem cells and platelet-rich plasma for knee osteoarthritis: prevalence and cost in South Florida.
        J Am Acad Orthop Surg. 2018; https://doi.org/10.5435/JAAOS-D-18-00343
        • Etulain J.
        Platelets in wound healing and regenerative medicine.
        Platelets. 2018; 29: 556-568
        • Hosseini S.
        • Taghiyar L.
        • Safari F.
        • et al.
        Regenerative medicine applications of mesenchymal stem cells.
        Adv Exp Med Biol. 2018; 1089: 115-141
        • Maniar H.H.
        • Tawari A.A.
        • Suk M.
        • et al.
        The current role of stem cells in orthopaedic surgery.
        Malays Orthop J. 2015; 9: 1-7
        • Akpancar S.
        • Tatar O.
        • Turgut H.
        • et al.
        The current perspectives of stem cell therapy in orthopedic surgery.
        Arch Trauma Res. 2016; 5: e37976
        • Feng H.
        Is stem cell therapy the future of orthopedics?.
        Knee Surg Relat Res. 2018; 30: 177-178
        • Cole B.J.
        • Seroyer S.T.
        • Filardo G.
        • et al.
        Platelet-rich plasma: where are we now and where are we going?.
        Sports Health. 2010; 2: 203-210
        • Im G.I.
        Clinical use of stem cells in orthopaedics.
        Eur Cell Mater. 2017; 33: 183-196
        • Garay-Mendoza D.
        • Villarreal-Martínez L.
        • Garza-Bedolla A.
        • et al.
        The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis.
        Int J Rheum Dis. 2018; 21: 140-147
        • Lamo-Espinosa J.M.
        • Mora G.
        • Blanco J.F.
        • et al.
        Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: multicenter randomized controlled clinical trial (phase I/II).
        J Transl Med. 2016; 14: 246
        • Nguyen P.D.
        • Tran T.D.-X.
        • Nguyen H.T.-N.
        • et al.
        Comparative clinical observation of arthroscopic microfracture in the presence and absence of a stromal vascular fraction injection for osteoarthritis.
        Stem Cells Transl Med. 2017; 6: 187-195
        • Bansal H.
        • Comella K.
        • Leon J.
        • et al.
        Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis.
        J Transl Med. 2017; 15: 141
      1. Available at: http://www.jrnlappliedresearch.com/articles/Vol11Iss1/Vol11%20Iss1Wei.pdf. Accessed March 4, 2019.

        • Shapiro S.A.
        • Kazmerchak S.E.
        • Heckman M.G.
        • et al.
        A prospective, single-blind, placebo-controlled trial of bone marrow aspirate concentrate for knee osteoarthritis.
        Am J Sports Med. 2017; 45: 82-90
        • Hadley C.J.
        • Shi W.J.
        • Murphy H.
        • et al.
        The clinical evidence behind biologic therapies promoted at annual orthopaedic meetings: a systematic review.
        Arthroscopy. 2019; 35: 251-259
        • Centeno C.J.
        • Busse D.
        • Kisiday J.
        • et al.
        Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
        Pain Physician. 2008; 11: 343-353
        • Pers Y.-M.
        • Rackwitz L.
        • Ferreira R.
        • et al.
        Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial.
        Stem Cells Transl Med. 2016; 5: 847-856
        • Jo C.H.
        • Lee Y.G.
        • Shin W.H.
        • et al.
        Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
        Stem Cells. 2014; 32: 1254-1266
        • Sekiya I.
        • Muneta T.
        • Horie M.
        • et al.
        Arthroscopic transplantation of synovial stem cells improves clinical outcomes in knees with cartilage defects.
        Clin Orthop Relat Res. 2015; 473: 2316-2326
        • Koh Y.-G.
        • Choi Y.-J.
        • Kwon S.-K.
        • et al.
        Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis.
        Knee Surg Sports Traumatol Arthrosc. 2015; 23: 1308-1316
        • Vega A.
        • Martín-Ferrero M.A.
        • Del Canto F.
        • et al.
        Treatment of knee osteoarthritis with allogeneic bone marrow mesenchymal stem cells: a randomized controlled trial.
        Transplantation. 2015; 99: 1681-1690
        • Koh Y.-G.
        • Choi Y.-J.
        Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis.
        Knee. 2012; 19: 902-907
        • Vangsness C.T.
        • Farr J.
        • Boyd J.
        • et al.
        Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.
        J Bone Joint Surg Am. 2014; 96: 90-98
        • Wong K.L.
        • Lee K.B.L.
        • Tai B.C.
        • et al.
        Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years’ follow-up.
        Arthroscopy. 2013; 29: 2020-2028
        • Glynn L.G.
        • Mustafa A.
        • Casey M.
        • et al.
        Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care.
        Pilot Feasibility Stud. 2018; 4: 93
        • Halpern B.
        • Chaudhury S.
        • Rodeo S.A.
        • et al.
        Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis.
        Clin J Sport Med. 2013; 23: 238-239
        • Taniguchi Y.
        • Yoshioka T.
        • Kanamori A.
        • et al.
        Intra-articular platelet-rich plasma (PRP) injections for treating knee pain associated with osteoarthritis of the knee in the Japanese population: a phase I and IIa clinical trial.
        Nagoya J Med Sci. 2018; 80: 39-51
        • Cole B.J.
        • Karas V.
        • Hussey K.
        • et al.
        Hyaluronic acid versus platelet-rich plasma: a prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis.
        Am J Sports Med. 2017; 45: 339-346
        • Raeissadat S.A.
        • Rayegani S.M.
        • Hassanabadi H.
        • et al.
        Knee osteoarthritis injection choices: platelet- rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial).
        Clin Med Insights Arthritis Musculoskelet Disord. 2015; 8: 1-8
        • Patel S.
        • Dhillon M.S.
        • Aggarwal S.
        • et al.
        Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial.
        Am J Sports Med. 2013; 41: 356-364
        • Dai W.-L.
        • Zhou A.-G.
        • Zhang H.
        • et al.
        Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials.
        Arthroscopy. 2017; 33: 659-670.e1
        • Shen L.
        • Yuan T.
        • Chen S.
        • et al.
        The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials.
        J Orthop Surg Res. 2017; 12: 16
        • Knoepfler P.S.
        From bench to FDA to bedside: US regulatory trends for new stem cell therapies.
        Adv Drug Deliv Rev. 2015; 82-83: 192-196
        • Halme D.G.
        • Kessler D.A.
        FDA regulation of stem-cell-based therapies.
        N Engl J Med. 2006; 355: 1730-1735
        • McLean K.
        • Gong Y.
        • Choi Y.
        • et al.
        Human ovarian carcinoma–associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production.
        J Clin Invest. 2011; 121: 3206-3219
        • Piuzzi N.S.
        • Ng M.
        • Kantor A.
        • et al.
        What Is the Price and Claimed Efficacy of Platelet-Rich Plasma Injections for the Treatment of Knee Osteoarthritis in the United States?.
        J Knee Surg. 2018; https://doi.org/10.1055/s-0038-1669953
        • Akhundov K.
        • Pietramaggiori G.
        • Waselle L.
        • et al.
        Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing.
        Ann Burns Fire Disasters. 2012; 25: 207-213
        • Piuzzi N.S.
        • Ng M.
        • Chughtai M.
        • et al.
        The stem-cell market for the treatment of knee osteoarthritis: a patient perspective.
        J Knee Surg. 2018; 31: 551-556